Indian Journal of Psychological Medicine
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Year : 2008  |  Volume : 30  |  Issue : 2  |  Page : 83-89

Structural cerebellar abnormalities in antipsychotic-naive schizophrenia: Evidence for cognitive dysmetria

1 Department of Psychiatry, NIMHANS, Bangalore-560 029, India
2 Department of Neuroimaging and Interventional Radiology, NIMHANS, Bangalore-560 029, India

Correspondence Address:
Rashmi Arasappa
Door No. 325, 2nd F Cross, 3rd Stage, 3rd Block, Basaveshwara Nagar, Bangalore-560 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7176.48479

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Background: "Cognitive dysmetria" has been proposed as a unifying model to explain the pathogenesis of schizophrenia. Most of the previous studies examining structural cerebellar abnormalities in schizophrenia were confounded by various factors like antipsychotic treatment, comorbid alcohol dependence, and low-resolution imaging procedure with manual morphometric analysis. In this study, we describe the first report of structural cerebellar abnormalities in antipsychotic-naive schizophrenia patients using high-resolution imaging (3.0 Tesla MRI). Aim: This study was aimed at examining the structural cerebellar abnormalities in antipsychotic-naive schizophrenia patients and its correlation with psychopathology. Methods: Brain imaging of 20 antipsychotic-naive schizophrenia patients and their age, gender, and years of education matched 20 healthy controls was done using 3.0 Tesla MRI machine. Image analysis was done using the optimized Voxel Based Morphometry (VBM), an automated unbiased technique. Results: Antipsychotic-naive schizophrenia patients had significant cerebellar gray matter volume deficits compared to healthy controls. The Scale for the Assessment of Negative Symptoms (SANS) score in patients had negative correlation with cerebellar gray matter volume. Conclusion: Structural cerebellar abnormalities and their negative correlation with negative syndrome in antipsychotic-naive schizophrenia patients support the cognitive dysmetria.

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