Indian Journal of Psychological Medicine
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 34  |  Issue : 2  |  Page : 170-175

Rapid response with ketamine on suicidal cognition in resistant depression


1 Department of Psychiatry, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
2 Department of Anaesthesiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
3 Department of Anaesthesiology, I.P.G.M.E.R, 244B, A.J.C Bose Road, Kolkata, West Bengal, India

Correspondence Address:
Om Prakash Singh
Department of Psychiatry, Burdwan Medical College and Hospital, Burdwan, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7176.101793

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Context: Suicidal ideation in depressed patients is a serious and emergent condition that requires urgent intervention. Intravenous ketamine, an N-methyl-D-aspartate (NMDA) antagonist, has shown rapid antidepressant effects, making it a potentially attractive candidate for depressed patients with suicidal risk. Aims: In India few studies have corroborated such findings; the present study aimed to assess the effectiveness and sustainability of antisuicidal effects of ketamine in subjects with resistant depression. Settings and Design: Single-center, prospective, 4 weeks, open-label, single-arm pilot study. Materials and Methods: Twenty-seven subjects with DSM-IV major depression (treatment resistant) were recruited. The subjects were assessed on Scale for Suicidal Ideation (SSI), 17-item Hamilton Depression Rating Scale (HDRS). After a 2-week drug-free period, subjects were given a single intravenous infusion of ketamine hydrochloride (0.5 mg/kg) and were rated at baseline and at 40, 80, 120, and 230 minutes and 1 and 2 days postinfusion. Results: The ketamine infusion was effective in reducing the SSI and HDRS scores, the change remained significant from minute 40 to 230 at each time point. Conclusions: The real strength of this study rests in documenting the rapid albeit short-lasting effect of ketamine on suicidal ideation in depressed patients.


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