Indian Journal of Psychological Medicine
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CASE REPORT
Year : 2013  |  Volume : 35  |  Issue : 4  |  Page : 413-416

Linezolid-induced near-fatal serotonin syndrome during escitalopram therapy: Case report and review of literature


1 Department of Psychiatry, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India
2 Department of Forensic Medicine and Toxicology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India

Correspondence Address:
Ranganath R Kulkarni
Department of Psychiatry, SDM College of Medical Sciences and Hospital, Dharwad 580 009, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7176.122245

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Linezolid is a synthetic antimicrobial agent of the oxazolidinone class with weak, nonspecific inhibitor of monoamine oxidase enzymes. Concomitant therapy with an adrenergic or serotonergic agent or consuming tyramine (>100 mg/day) may induce serotonin syndrome (SS). We present a case report of near-fatal adverse interaction between linezolid and escitalopram inducing SS in a 65-year-old woman with sepsis, under empirical antibiotic treatment. This report also summarizes the current relevant literature as identified via PubMed, EMBASE, and PsycINFO, supplemented with a manual search of cross references.


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