Indian Journal of Psychological Medicine
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ORIGINAL ARTICLE
Year : 2015  |  Volume : 37  |  Issue : 4  |  Page : 419-422

Effect of transcranial direct current stimulation on prefrontal inhibition in schizophrenia patients with persistent auditory hallucinations: A study on antisaccade task performance


1 Department of Psychiatry, The Schizophrenia Clinic, Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2 University of Sussex, Brighton, United Kingdom

Correspondence Address:
Ganesan Venkatasubramanian
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru - 560 029, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7176.168584

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Background: Deficient prefrontal cortex inhibitory control is of particular interest with regard to the pathogenesis of auditory hallucinations (AHs) in schizophrenia. Antisaccade task performance is a sensitive index of prefrontal inhibitory function and has been consistently found to be abnormal in schizophrenia. Methods: This study investigated the effect of transcranial direct current stimulation (tDCS) on antisaccade performance in 13 schizophrenia patients. Results: The tDCS resulted in significant reduction in antisaccade error percentage (t = 3.4; P = 0.005), final eye position gain (t = 2.3; P = 0.042), and AHs severity (t = 4.1; P = 0.003). Conclusion: Our results raise the possibility that improvement in antisaccade performance and severity of AH may be mechanistically related.


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