Indian Journal of Psychological Medicine
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Year : 2016  |  Volume : 38  |  Issue : 2  |  Page : 97-100

Cytokines in schizophrenia: Hope or hype?

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA

Correspondence Address:
Maju Mathew Koola
Clinical Research Program, Sheppard Pratt Health System, 6501 N Charles Street, Baltimore, Maryland 21204
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7176.178766

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Although there is a cumulative evidence for the inflammation pathophysiology in schizophrenia, it has not been conclusively proven yet. One reason for this is the lack of studies that have controlled for major confounding factors such as obesity, smoking, antipsychotic use, and stress. The studies in which the major confounding factors were controlled were done in subjects in acute relapse and in treatment-resistant schizophrenia. To date, no studies have been done in stable outpatients with schizophrenia controlling for major confounding factors. Data on cerebrospinal fluid cytokines in large sample independent of confounding factors are also lacking. The efficacy signal from anti-inflammatory medications in schizophrenia has been modest. In this study, the inconsistent and nonvalidated cytokine findings independent of the confounding factors are discussed.

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