|Year : 2016 | Volume
| Issue : 3 | Page : 207-212
A Cross-sectional, comparative study of insight in schizophrenia and bipolar patients in remission
Arul Saravanan Ramachandran1, Rajkumar Ramanathan1, Samir Kumar Praharaj2, Haridas Kanradi2, Podila Satya Venkata Narasimha Sharma2
1 Department of Psychiatry, SRM MCH and RC, Kancheepuram, Tamil Nadu, India
2 Department of Psychiatry, KMC, Manipal University, Manipal, Karnataka, India
|Date of Web Publication||27-May-2016|
Dr. Arul Saravanan Ramachandran
403, New B-Block, SRM Medical Staff Quarters, Potheri, Kancheepuram - 603 203, Tamil Nadu
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Aims: To study insight correlates in schizophrenia and bipolar mood disorder in remission among out-patients attending the Psychiatry Department of a Tertiary Care Hospital. Settings and Design: In a cross-sectional, naturalistic study, adult patients with schizophrenia and bipolar mood disorder in remission (n = 80; schizophrenia-40, mania-20, bipolar depression-20) were compared on insight measures and clinical correlates. Materials and Methods: Scale to Assess the Unawareness of Mental Disorders (SUMD) was used as the main tool to assess current and past measures of insight. Hogan's Drug Attitude Inventory was used to assess the drug attitude and compliance. Positive and Negative Symptom Scale for Schizophrenia, Young's Mania Rating Scale, and HAMD were used to rate psychopathology. Clinical Global Improvement was used as a screening tool for remission. Statistical Analysis: For comparison of the three clinical groups, analysis of variance and Chi-square test were used. In the post-hoc analysis, the Ryan-Einot-Gabriel-Welsch test was used to find the group difference. Results: About 40% in the schizophrenia group were unaware of their mental illness as against none in the bipolar group. The awareness of mental disorder for the current period, the awareness of the achieved effects of medications, and the awareness of social consequence was better in the bipolar group. The drug attitude (compliant positive attitude) increased as the SUMD item scale decreased or in other words, as the insight improved. Conclusions: Insight, both current and retrospect, showed significant differences between the schizophrenia and bipolar patients. Insight is significantly correlated with the observed compliance and drug attitude of the patient groups.
Keywords: Bipolar mood disorder, drug compliance, insight, schizophrenia
|How to cite this article:|
Ramachandran AS, Ramanathan R, Praharaj SK, Kanradi H, Sharma PS. A Cross-sectional, comparative study of insight in schizophrenia and bipolar patients in remission. Indian J Psychol Med 2016;38:207-12
|How to cite this URL:|
Ramachandran AS, Ramanathan R, Praharaj SK, Kanradi H, Sharma PS. A Cross-sectional, comparative study of insight in schizophrenia and bipolar patients in remission. Indian J Psychol Med [serial online] 2016 [cited 2019 Jun 16];38:207-12. Available from: http://www.ijpm.info/text.asp?2016/38/3/207/183085
| Introduction|| |
Insight is the “conscious recognition of one's own condition.” It refers to the conscious awareness and understanding of one's own psychodynamics and symptoms of maladaptive behavior, highly important in effecting changes in the personality, and behavior of a person'. In psychiatry, insight is defined as the degree of personal awareness and understanding of illness. However, its overall meaning in psychiatry remains unclear.,,,,, Emerging consensus accepts insight as both multidimensional and continuous construct. The association between dimensions of insight and sociodemographic variables, psychopathology, and severity are active areas of research. McEvoy et al. failed to identify any relationship between the degree of insight and severity of psychopathology. Further, the changes in insight scores during the hospital treatment did not vary consistently with the psychopathology scores. However, David et al., in their subsequent study reported a moderate correlation between insight and severity of illness in schizophrenia. Another study by Amador and Strauss, reported a moderate correlation between insight and age at onset, course of illness, and number of hospitalizations. They found moderate correlation between current awareness of mental disorder and positive symptoms.
Studies on insight done in India also reflect such mixed results. Kulhara et al., showed consistent negative correlation between Brief Psychiatric Rating Scale scores and insight as measured with schedule for assessment of insight in schizophrenia and affective disorder. Aga et al. showed significant positive association between insight and number of episodes and past treatment. Anna and Saravanan, using the Scale to assess the Unawareness of Mental Disorders (SUMD), reported significant positive correlation between awareness of dimensional measures of abnormal experiences such as hallucination and delusion with psychopathology in schizophrenia. In the study by Armstrongh et al., there was no consistent relationship between the changes in insight and changes in psychopathology among 25 in-patients with schizophrenia.
In studies comparing insight in schizophrenia and bipolar disorder, Michalakeas et al. reported that patient with schizophrenia and mania did not differ on insight (using insight and treatment attitudes questionnaire), but both groups had significantly lower insight scores than patients with bipolar depression. Amador et al. found no difference in insight measures between schizophrenia and mania. Another study reported that the presence of psychotic features did not significantly affect insight level in manic patients at discharge from the acute ward. Pini et al. reported no difference in insight between patients with schizophrenia and bipolar disorder. However, Yen et al., comparing insight in-patients with schizophrenia and bipolar disorder in remission, reported that bipolar patients with psychotic features had lower levels of insight than those without psychotic features. A 1-year European outpatient, observational study of 903 patients, using SUMD to measure insight concluded that insight and medication adherence are closely related.
| Materials and Methods|| |
The aim was to study insight correlates in schizophrenia and bipolar mood disorder in remission among outpatients attending the Psychiatry Department of a Tertiary Care Hospital. The objectives were (a) to study the clinical correlates of insight in schizophrenia and BPMD, (b) to correlate the insight variables with psychopathology, (c) to correlate insight with compliance and drug taking attitude.
The present study is a cross-sectional study done at the Kasturba Medical College Hospital, Manipal, Karnataka, between February 2011 and August 2011. The Institutional Ethics Committee approval was obtained prior. Written informed consent was obtained both from patients and guardians. All patients who were diagnosed with International Classification of Disease-10 schizophrenia or bipolar mood disorder were screened for the study. The sociodemographic profile and the clinical details were obtained from both the patient and the relative. Subjects were then assessed on the various instruments. Any subject scoring more than 2 on the Clinical Global Improvement (CGI) - “severity of illness” scale was considered actively ill and was excluded from the study. The other exclusion criteria included patients who had any recent admission (within prior 1 month), patients with other comorbid psychiatric diagnoses (except alcohol use and tobacco dependence syndrome), and patients with neurological disorders or organic brain syndrome.
Using purposive sampling, 115 patients were screened. Eleven subjects were excluded as their last episode was well within 1 month. Twenty-four more were excluded, for they had CGI score >2 severity. Finally, a total of 80 patients were included in the study. Among them, 40 were selected with a diagnosis of schizophrenia, and another 40 with the diagnosis of bipolar mood disorder – with 20 patients who had their most recent past episode as mania and another 20 patients who had depression.
A semi-structured proforma was used for collecting the sociodemographic profile and relevant clinical data. We used the Positive and Negative Symptom Scale for Schizophrenia (PANSS) in schizophrenia, the Hamilton Depression Rating Scale (HDRS), and the Young's Mania Rating Scale (YMRS) were used for bipolar disorder. For insight measurement, we used the Scale to Assess Unawareness of Mental Disease (SUMD). The Hogan's Drug Attitude Inventory was used to drug attitude and compliance.
The computerized form of SPSS, version 16.0 (SPSS Inc., Chicago, IL, USA) was used for the analysis. Chi-square test and independent t-test were used for categorical and continuous data, respectively. For comparison between the three groups-schizophrenia, mania, and depression on the continuous variables, analysis of variance was used. In the post-hoc analysis, the Ryan-Einot-Gabriel-Welsch test was used to find the group difference.
| Results and Discussion|| |
The mean age of the study population was 35.2 years (standard deviation [SD] = 9.48) in the schizophrenia group, and in bipolar group, it was 36.02 years (SD = 9.7). The average illness duration is comparable in both the groups. The mean number of admission is 4.2 (SD = 3.4) and 5.5 (SD = 4.1) in the schizophrenia group and bipolar group, respectively.
[Table 1] highlights sociodemographic variable, parenteral depot medication use and observed compliance in the study group. Majority of the patients were in the age group of 30-40 years. The schizophrenia and bipolar groups did not vary much in their demographic profile. Males were 21.25%, and females were 28.75% in the schizophrenia group. In the mania group, there were 17.5% males and 7.5% females. In the depression group, 16.25% were males and 8.75% were females. 66.25% of the study group were Hindus. 27.5% were Christians, and the remaining 6.25% were Muslims. Majority belonged to the joint family type, which represents 57.5% of the study population. 58.25% of the study group had at least primary school level of education. 23.75% of the schizophrenia group were employed as against the 20% and 17.5% of people employed in the mania and depression group, respectively. The number of those who were unemployed was significantly high in the schizophrenia group as compared to the other two groups. 51.25% of the study population is from rural areas. About 70% of the study population were married and lived with spouse. 35% belonged to the schizophrenia group, 13.75% from the mania, and 21.25 from the depression group. 23.75% were unmarried, and the remaining 6.25% were single in status either separated or divorced or widowed.
|Table 1: Group difference in sociodemographic and clinical variables in categorical variables between schizophrenia and bipolar patients|
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On comparing the sociodemographic variables, it was found that both schizophrenia and bipolar patient groups were similar in most variables except sex and employment. The study population shows a slightly over-representation of females in the schizophrenia group and males in the mania group. Furthermore, the employment status was significantly better in the bipolar group (37.5%) compared to schizophrenia group (23.8%). About 18.8% in the schizophrenia group were dependents as against the bipolar group in which only 7.5% were dependent. This difference was statistically significant.
About 23.75% of the schizophrenia group had been under parenteral depot medication at least once during their course of treatment, whereas only 6.25% and 3.75% of the mania and depression group, respectively, had received depot medication at least once in the past. This is in agreement with previous studies such as by Mahadun and Marshall, in schizophrenia wherein those who were on oral antipsychotics had better insight than those on depot medications.
With regard to the observed compliance, as reported by the caregiver, 21.25% of the schizophrenia group, 12.5% in mania group, and 13.75% in the depression group took the medications on their own. 6.25% in schizophrenia group, 7.5% of mania group, and 8.75% of depression group took the medications regularly only if and when given by the caregiver. 22.5% of the schizophrenia group, 5% in mania, and 2.5% in depression group refuse to take drugs regularly.
Comparison of unawareness of mental disorder
In this study, it was found that 60% of schizophrenia patients were aware of the mental disorder in the current period. Among this, 30% were aware, and the other 30% were somewhat aware of their illness. The remaining 40% were unaware of the mental illness. Literature data on the prevalence of unawareness of illness ranged from 40% to 85% in various studies.,,,,, The prevalence of unawareness in this study also falls within this range. In the bipolar group, 67.5% were aware of the mental illness, and 32.5% were somewhat aware of their illness, with none reporting unawareness of mental illness. In the study by Yen et al., 39.09% of schizophrenic, 36.36% of psychotic bipolar, and 9.37% of nonpsychotic bipolar patients were found to have impaired insight even during remission. It is also noted that although 40% of schizophrenia patients are unaware of mental disorder only 27.5% are unaware of medication effects, and 37.5% are unaware of social consequences. This means that a person may be unaware of mental disorder still be aware of medication effects and social consequences. Though patients may fail to acknowledge the presence of mental illness at a conceptual level, they may still be aware of the beneficial effects of the drugs in the past, which could possibly explain this.
Comparison of insight dimensions in schizophrenia and bipolar groups
The awareness of mental disorder for the current period [Table 2] was better in the bipolar group as compared to the schizophrenia group. Furthermore, the awareness of achieved effects of medication and the awareness of social consequence of mental disorders was also better in the bipolar group as compared to the schizophrenia group. This trend was found true when the total scores of SUMD were computed wherein the total awareness was significantly better in the bipolar group as compared to the schizophrenia group, and this difference was statistically significant.
|Table 2: Group characteristics on SUMD current items in schizophrenia and bipolar groups|
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The dimensional awareness of mental illness in the past [Table 3] as measured by the general items of the SUMD show that the bipolar group had a better awareness of mental illness in the past as compared to the schizophrenia group. Furthermore, the awareness of achieved effects of medication in the past along with the awareness of social consequence in the past was statistically significant.
|Table 3: Group characteristics on SUMD past items in schizophrenia and bipolar groups|
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Comparison of the subscale items of Scale to assess the Unawareness of Mental Disorders between the schizophrenia and bipolar group
When the SUMD subscale items are compared, the awareness of hallucinations (item 4), poor control of aggressive impulses (item 11), and poor social relationships (item 20) showed statistically significant difference between the groups with the awareness being poorer in the schizophrenia group. Similar studies including Braw et al. show that schizophrenia patients displayed poorer insight, and they were also less aware of their anhedonia-asociality.
Difference of insight scale among the three groups
When the SUMD general items were compared among groups [Table 4], there was significant difference between the schizophrenia group and the other two bipolar groups in almost all the three dimensions of the general item, both in the current and in the retrospective. It showed that insight was poorer in schizophrenia group and bipolar group, and within the bipolar group it was poorer in the depression group. This is in contrast to the few studies that have compared the levels of insight in these disorders had found no substantial difference between patients with bipolar disorder and schizophrenia. However, in the recent study by Yen et al., in schizophrenia, bipolar I, and depressive disorder patients, patients with depressive disorder had higher levels of insight than did patients with schizophrenia.
|Table 4: Post-hoc analysis of group differences in sociodemographic and clinical variables among schizophrenia, mania, and depression patients|
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Comparison of psychopathology with insight
When general psychopathology, as measured by the PANSS scale, is analyzed with the clinical variables, it shows a significant positive correlation between age and the PANSS negative subscale. Increase in age is correlated with increase in the negative symptoms. in addition, the illness duration and total number of past admissions were positively correlated with PANSS negative and PANSS total score, which is in agreement with most of the studies done in schizophrenia course and outcome. In the mania group, when YMRS was compared it did not show any significant correlation with the clinical variables. In contrast, the depression group, as measured by HDRS, shows significant positive correlation with age, illness duration, and total number of past admissions. The study done by Peralta and Cuesta, and McEvoy et al. showed only modest correlation between insight and psychopathology as ours.
Limitations and strengths
A single point assessment, as done in this study, fails to throw more light on the dynamic nature of the insight. Sample has been collected only from the out-patients, and hence, the results may not be generalizable to all patients. However, this being a naturalistic study design, it shows the real world scenario of insight in-patients under remission. The study also looked into the drug taking attitude which is considered a different construct from insight.
| Conclusion|| |
This study result shows that there is significant difference in the insight, both current and the past, in the schizophrenia and the bipolar group of patients even during remission. Insight is significantly correlated with the observed compliance and drug attitude of the study participants.
Our sincere thanks to all the participants of this study and their carers.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Amador XF, Strauss DH, Yale SA, Gorman JM. Awareness of illness in schizophrenia. Schizophrenia Bulletin 1991;17:113-32.
Cuesta MJ, Peralta V. Lack of Insight in Schizophrenia. Schizophrenia Bulletin, 1994;20:359-66
David AS. Insight and psychosis. British journal of Psychiatry 1990;156:798-808.
Marková IS, Berrios GE. The meaning of Insight in clinical psychiatry. British Journal of Psychiatry 1992;160:850-60.
Takai A, Uematsu M, Ueki H. Sone K. Insight and its related factors in chronic schizophrenic patients: A preliminary study. European Journal of Psychiatry 1992;6:159-70.
Vaz FJ, Bejar A, Casado M. Insight, psychopathology, and interpersonal relationships in schizophrenia. Schizophrenia Bulletin 2002;28:311-17.
Amador XF, Strauss DH. Poor insight in schizophrenia. Psychiatric Quarterly 1993;64:305-18.
McEvoy JP, Aland JJr, Wilson WH, Guy W. Hawkins L. Measuring chronic schizophrenic patients' attitudes toward their illness and treatment. Hospital and Community Psychiatry 1981;32:856-8.
McEvoy JP, et al
. Insight and clinical outcome of schizophrenia patients. Journal of Nervous and Mental Disorder 1989;177:48-51.
David AS, Alec B, Alison R, Osvaldo A. British journal of Psychiatry 1992;16:599-602.
Kulhara P, Chakrabarti S, Basu D. Insight and Psychosis: An empirical inquiry. Indian Journal of Social Psychiatry 1992;8:40-4.
Aga VM, Agarwal AK, Gupta SC. The relationship of insight to psychopathology in schizophrenia:A crosssectional study. Indian J Psychiatry, 1995;37:129-35.
Anna T, Saravanan B. Indian Journal of Psychiatry 2000;42:421-6.
Armstrongh KP, Chandrasekaran R, Perme B. Insight, psychopathology & schizophrenia. Indian J Psychiatry 2002;44:332-6.
Michalakeas A, Skoutas C, Charalambous A, Peristeris A, Marinos V, Keramari E. Insight in schizophrenia and mood disorders and it relation to psychopathology. Acta Psychiatrica Scandinavica 1994;90:46-9.
Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark S, et al
. Awareness of illness in schizophrenia, schizoaffective and mood disorders. Archives of General Psychiatry 1994;51:826-36
Peralta V, Cuesta M. Lack of insight in mood disorders. Journal of Afffective disorders 1998;49:55-8.
Pini S, Cassano GB, Dell'Osso L, Amador XF. Insight into illness in schizophrenia schizoaffective disorder, and mood disorders with psychotic features. American Journal of Psychiatry 2001;158:122-5.
Yen CF, Chen CC, Cheng CP, Yen CN, Lin HC, Ko CH, et al
. Comparisons of insight in schizophrenia, bipolar I disorder, and depressive disorders with and without comorbid alcohol use disorder. 2008;62:685-90.
Diego N, William M, Tamas T, Jaume A, Susanne K, Josep MH. Relationship of insight with medication adherence and the impact on outcomes in patients with schizophrenia and bipolar disorder: results from a 1-year European outpatient observational study. BMC Psychiatry 2015,15:189.
Mahadun PN, Marshall M. Insight and treatment attitude in schizophrenia: comparison of patients on depot and atypical antipsychotics. Psychiatric Bulletin 2008;32:53-6. doi: 10.1192/pb.bp.107.015875.
[Table 1], [Table 2], [Table 3], [Table 4]