Indian Journal of Psychological Medicine
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Year : 2016  |  Volume : 38  |  Issue : 4  |  Page : 366-369

Postinjection delirium/sedation syndrome with olanzapine depot injection

1 Asha Bipolar Clinic, Asha Hospital, Banjara Hills, Hyderabad, Telangana, India
2 Department of Psychiatry, Katuri Medical College and Hospital, Eudulapalem, Guntur, Andhra Pradesh, India

Correspondence Address:
Starlin Vijay Mythri
402 B, Saincher Palace Apartment, East Marredpally, Secunderabad - 500 026, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7176.185946

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After 1 year of introduction of olanzapine long-acting injectable (LAI) in India, many psychiatrists believe that it is a very affordable, well-tolerated, and effective second generation long-acting antipsychotic depot compared to not well tolerated but cheap first generation antipsychotic depots and to other second generation depots which are costly. However, reports of its possible adverse events in clinical settings are not yet published. We report what probably might be the first case of postinjection delirium/sedation syndrome (PDSS) in India. Although the occurrence is uncommon, incorrect understanding of this event may hinder the future use of the potentially useful olanzapine LAI. We review the available literature on the proposed diagnostic guidelines, mechanism of this event, precautions, and management of PDSS.

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