Indian Journal of Psychological Medicine
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Year : 2017  |  Volume : 39  |  Issue : 2  |  Page : 209-212

Delayed Stevens–Johnson syndrome secondary to the use of lamotrigine in bipolar mood disorder

1 Department of Critical Care Medicine, Geisinger Medical Center, Danville, PA 17821, USA
2 Department of Internal Medicine, Norvic International Hospital, Kathmandu, Nepal
3 Dental Surgeon, Oracare Periodontal Clinic, Kathamandu, Nepal
4 Department of Internal Medicine Possible Health, Achham, Nepal

Correspondence Address:
Kunal Kishor Jha
Department of Critical Care Medicine, Geisinger Medical Center, Danville, PA 17821
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7176.203130

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Lamotrigine is a mood-stabilizing drug used in maintenance treatment of bipolar I disease. There are adverse effects with lamotrigine such as a headache, blurred vision, diplopia, somnolence, ataxia, dizziness, rash, Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis. SJS is a life-threatening, blistering mucocutaneous disease. SJS is characterized by the presence of flat, diffuse erythematous maculopapular rashes with the involvement of <10% of the body surface area. Standard trigger is drugs including anticonvulsants, antibiotics, and Mycoplasma pneumoniae infection. We report a case where a patient developed SJS secondary to delayed-type hypersensitivity reaction after 6 months of the use of lamotrigine, while his initial response during the first 6 months did not show any sign of SJS.

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