Indian Journal of Psychological Medicine
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CASE REPORT
Year : 2017  |  Volume : 39  |  Issue : 5  |  Page : 682-684

Clozapine-induced acute hypertriglyceridemia


Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India

Correspondence Address:
Ajeet Sidana
Department of Psychiatry, Government Medical College and Hospital, Sector-32, Chandigarh - 160 030
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7176.217031

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The aim of this study is to highlight the association between the use of clozapine and the early development of hypertriglyceridemia, a condition that substantially increases the risk of cardiovascular events and other medical complications. A 34-year-old female with a background history of schizophrenia presented with acute elevation of serum triglycerides and cholesterol within 2 weeks of starting clozapine. Her metabolic parameters normalized following discontinuation of clozapine. Possible hypotheses for lipid dysregulation with atypical antipsychotics include weight gain, dietary changes, and development of glucose intolerance; however, some other factors may be responsible for this rapid escalation of lipid levels. Lipid and metabolic profiles should be closely monitored in patients receiving clozapine to facilitate early detection and intervention to prevent further health complications.


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