Indian Journal of Psychological Medicine

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 37  |  Issue : 2  |  Page : 154--158

Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia


Arshad Hussain, Mansoor Ahmad Dar, Rayees Ahmad Wani, Majid Shafi Shah, Mohd Muzzaffar Jan, Yasir A Malik, Rajesh Kumar Chandel, Mushtaq Ahmad Margoob 
 Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Dr. Mansoor Ahmad Dar
Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir
India

Background: Resistance to pharmacotherapy is one of the major challenges in the management of obsessive-compulsive disorder (OCD). OCD being a quite prevalent disorder, this resistance adds to the disability. Different strategies are being employed to counter this resistance, one of them being augmentation with glutamatergic modulators. Lamotrigine is being used for same since the recent past with mixed results. Objective: The aim was to study the role of lamotrigine augmentation in serotonin reuptake inhibitor (SRI) resistant OCD patients. Methodology and Results: This study was carried by studying the case sheets of SRI resistant cases having already completed the treatment. A total of 22 cases sheets over 2 years met the study criteria with a mean age of mean age of 34.14 years. Over a period of 16 weeks, with a mean lamotrigine dose of 150 mg/day, 20 out of 22 patients had shown a significant response. The mean decrease in Yale-Brown Obsessive Compulsive Scale score was 67.23% with a baseline score of 28.87. There was a similar change on different domains of World Health Organization quality of life (P = 0.00564). Conclusion: Lamotrigine augmentation to on-going treatment with SRIs may be an effective move in case of SRI resistant OCD patients.


How to cite this article:
Hussain A, Dar MA, Wani RA, Shah MS, Jan M, Malik YA, Chandel RK, Margoob MA. Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia.Indian J Psychol Med 2015;37:154-158


How to cite this URL:
Hussain A, Dar MA, Wani RA, Shah MS, Jan M, Malik YA, Chandel RK, Margoob MA. Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: A retrospective case review from South Asia. Indian J Psychol Med [serial online] 2015 [cited 2019 Nov 22 ];37:154-158
Available from: http://www.ijpm.info/article.asp?issn=0253-7176;year=2015;volume=37;issue=2;spage=154;epage=158;aulast=Hussain;type=0