Indian Journal of Psychological Medicine

REVIEW ARTICLE
Year
: 2020  |  Volume : 42  |  Issue : 1  |  Page : 22--29

Repurposing potential of ketamine: Opportunities and challenges


CS Gautam, Sonia S Mahajan, Jatin Sharma, Harmanjit Singh, Jagjit Singh 
 Department of Pharmacology, Government Medical College and Hospital, Chandigarh, Punjab, India

Correspondence Address:
Dr. Harmanjit Singh
Department of Pharmacology, Government Medical College and Hospital, Chandigarh, Punjab
India

Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor which also interacts with various other receptors that account for its myriad actions. Originally approved as a general anesthetic, it is being explored to be repurposed for numerous other indications such as depressive disorders, suicidal ideation, substance-use disorders, anxiety disorders, chronic pain, refractory status epilepticus, and bronchial asthma exacerbations. Numerous trials are ongoing for the same. The nasal spray of esketamine, a more potent S (+) enantiomer of ketamine, has been approved by the United States Food and Drug Administration (USFDA) for treatment-resistant depression along with the oral antidepressants. However, there are concerns about its safety on long term use, given its psychedelic effects and potential abuse. In this review, we discuss repurposing ketamine for potential therapeutic use and about the safety concerns related to ketamine and esketamine.


How to cite this article:
Gautam C S, Mahajan SS, Sharma J, Singh H, Singh J. Repurposing potential of ketamine: Opportunities and challenges.Indian J Psychol Med 2020;42:22-29


How to cite this URL:
Gautam C S, Mahajan SS, Sharma J, Singh H, Singh J. Repurposing potential of ketamine: Opportunities and challenges. Indian J Psychol Med [serial online] 2020 [cited 2020 Jan 22 ];42:22-29
Available from: http://www.ijpm.info/article.asp?issn=0253-7176;year=2020;volume=42;issue=1;spage=22;epage=29;aulast=Gautam;type=0